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Addison's Disease PDF Print E-mail
Written by Robert A Wilson   
Thursday, 15 February 2007
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Addison's Disease
What your doctor can do
What you can do

Addison's disease, or adrenal insufficiency, is a slow and progressive failure of adrenal gland function. Normally functioning adrenal glands produce hormones (such as cortisol) that help regulate a number of important body functions. In most cases, an autoimmune disorder (where the immune system attacks the adrenal glands) is the cause. Adrenal insufficiency can also occur in association with other hormone gland defects, which cause underactive thyroid or slow sexual development. Gradual loss of adrenal hormones will eventually produce symptoms, and in situations involving extra stress, such as an injury or infection, severe additional symptoms can develop. This abrupt worsening is called an Addisonian crisis, or acute adrenal insufficiency, and can be fatal if not treated. Your risk of adrenal insufficiency increases with stress, diabetes, surgery, anticoagulant (blood thinner) treatment, and abruptly discontinuing cortisone (e.g., prednisone) drugs or changing dosage abruptly.

Symptoms may include:

  • Muscle weakness and fatigue
  • Nausea, vomiting, abdominal pain, diarrhea, and weight loss
  • Craving for salty foods
  • Low blood pressure, which may cause faintness and dizziness, especially with rising from lying or sitting positions
  • Dark tanning of the skin on non-exposed areas and often more on scars, elbows and knees, lips, and skin folds
  • Depression, anxiety, or irritability
  • Abnormal or absent menstrual periods
  • Acute Adrenal Insufficiency (Addisonian crisis) may cause:
  • Severe pain in the abdomen, low back or legs
  • Severe vomiting and diarrhea
  • Low blood pressure
  • Unconsciousness or coma


Last Updated ( Friday, 08 February 2008 )
 
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