Common Side Effects:

• May occur during the first few days after beginning therapy, but usually resolve:
• Cheilitis (lip inflammation); dry mouth, lips; dry, irritated eyes; bone, joint or muscle pain, dry nose, nosebleeds, an intolerance to contact lenses, nausea, vomiting, stomach ache, changes in appetite, headache, skin sensitivity to sunlight

Serious Side Effects:

• Notify your doctor immediately if you experience any of the following:
• Severe abdominal pain; bowel pain; diarrhea; rectal bleeding; jaundice (yellowing of the skin and eyeballs); dark urine; ringing in your ears or hearing loss (may become permanent); vision problems (sudden loss of night vision); fainting; frequent urination and thirst (varying blood sugar levels); muscle weakness, convulsions, or slurred speech
• Pseudotumor cerebri - Severe headache, blurred vision, dizziness, nausea and vomiting. This may indicate increased pressure in the brain.
• Mental problems - Depression; suicidal thoughts; loss of appetite; feelings of sadness, irritability, fatigue; problems with concentration; withdrawal from family and friends; and difficulty with sleeping
• Female Patients - Birth defects, premature births, and death in babies
• Allergic reaction symptoms such as a red skin rash; itching; swelling of the face, lips, tongue, and throat; wheezing; chest pain; and difficulty breathing